Reducing Chemical Exposure in Biopharma Laboratories Without Compromising Contamination Control

• Navigate exposure monitoring challenges for sterilising agents with limited regulatory guidance by assessing peracetic acid, hydrogen peroxide and associated degradation products, drawing on available ACGIH and EPA guidance alongside employee-reported exposure symptoms to inform risk assessments
• Reduce employee exposure through safer cleaning practices and alternative sterilisation approaches by exploring Rocket Pharmaceuticals' experience replacing excessive sterilant use in a laboratory with scheduled ionised hydrogen peroxide cleaning, supported by exposure monitoring, ventilation controls and collaboration with facilities teams
• Overcome resistance to changing established cleaning procedures without compromising safety standards by engaging laboratory staff, encouraging incident reporting and using exposure monitoring and bioburden testing to evaluate proposed changes to cleaning frequency and chemical selection

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